Brehme studied on the Hochschule für Musik in Berlin. In 1928 he recognized a position on the Stuttgart Hochschule für Musik where he liked an extended and varied profession. Brehme constructed in the German Intimate custom, and his opera =Der Uhrmacher von Strassburg= was inspired by =Die Meistersinger= by Wagner. Afterwards works such as for example his Second Symphony and the next Piano Concerto are created with 12-take note series.